The demand for mouth dissolving tablets has been growing, during the last decade especially for geriatric and pediatric patients because of swallowing difficulties. Domperidone, an antiemetic drug, has been used as an add on treatment in adults and children. As precision of dosing and patient’s compliance become important prerequisite for quick relief from emesis, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while traveling and better compliance. Hence aim of this study is to prepare fast disintegrating tablets of Domperidone by wet granulation. In the present research study, Sodium Starch Glycolate, was taken as super disintegrant and starch paste as a binder for the study The disintegrant incorporated during the wet granulation process as extragranular incorporation.Different concentration of Sodium Starch Glycolate, and starch paste as a binder prepared and combine effect was observed. All formulations were evaluated for characteristics such as hardness, friability, disintegration time and Dissolution rate. An effective, pleasant tasting formulation was found to have a good hardness of 3 kg/cm2, dispersion time of 31 seconds and in vitro drug release of not less than 99% within 30 minutes. The drug release was found to be comparable with the marketed dispersible tablet.
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